Well-meaning commentators needlessly snipe back and forth while espousing their analyses of the pros and cons of either the traditional nonprofit model or those more aligned with a business-oriented approach. Nonprofits must continuously strive for innovation. We must constantly review methodologies and find areas for improvement—just like any nonprofit. Above all, in our specific field, we must find ways to put treatments into the hands of those who need them. Commentators can call it what they want; we call it effective drug development success.